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Development of Meta-Server for Prediction of Mutations Effects on Protein Function
Lisák, Peter ; Burgetová, Ivana (referee) ; Jaša, Petr (advisor)
This bachelor thesis deals with analysis of genomic data, more specifically prediction of effects of mutations on protein function using a protein sequence or tertiary structure. The theoretical introduction describes the basics of genetics and bioinformatics and is followed by description of selected prediction tools such as SIFT, MAPP and AUTO-MUTE. A unified interface for work with different tools is proposed in the thesis. The meta-server interface allows running a computation and collecting results from one site. meta-server combines results of implemented tools and provides a consensual prediction, which is expected to be more accurate than the results from individual tools. Finally, testing of meta-server on the real data and comparisons of predictions with the experimentally obtained results are presented.
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Security and Performance Analysis of Avalanche Distributed Consensus Protocol
Sapák, Filip ; Malinka, Kamil (referee) ; Perešíni, Martin (advisor)
V tejto práci sme sa zaoberali analýzou "Proof-of-Stake (PoS) distribuovaného konsenzuálneho protokolu Avalanche, problematikou blockchainu, konsenzuálnych algoritmov a simulačnými nástrojmi určenými na simuláciu blockchainu. Po oboznámení sa so všetkými potrebnými skutočnosťami, práca pokračuje implementáciou simulátora konsenzuálneho algoritmu implementovaného v protokole Avalanche, ktorý napodobňuje fungovanie Avalanche konsenzu. Experimenty so simulátorom boli vykonané s rôznymi parametrami a pomohli nám pochopiť vlastnosti Avalanche.
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Security and Performance Analysis of Avalanche Distributed Consensus Protocol
Sapák, Filip ; Malinka, Kamil (referee) ; Perešíni, Martin (advisor)
V tejto práci sme sa zaoberali analýzou "Proof-of-Stake (PoS) distribuovaného konsenzuálneho protokolu Avalanche, problematikou blockchainu, konsenzuálnych algoritmov a simulačnými nástrojmi určenými na simuláciu blockchainu. Po oboznámení sa so všetkými potrebnými skutočnosťami, práca pokračuje implementáciou simulátora konsenzuálneho algoritmu implementovaného v protokole Avalanche, ktorý napodobňuje fungovanie Avalanche konsenzu. Experimenty so simulátorom boli vykonané s rôznymi parametrami a pomohli nám pochopiť vlastnosti Avalanche.
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The German Energiewende: Consensual Process ?
Slaba, Martin ; Nigrin, Tomáš (advisor) ; Svobodová, Tereza (referee)
This bachelor thesis examines two very important subparts of the German energy revolution called Energiewende, specifically the level of consensus of the population with the costs of the whole transformation reflected in rising electricity prices and the necessity of expanding and building new power grid sections. The coalition government of SPD and the Greens, which led the state in years 1998-2005 started the whole process by announcing the nuclear phase-out of German Federal Republic and by implementing a renewable energy law (Erneubare Energien Gesetz, EEG) that serves as an instrument through which the renewable energy sources are being subsidized. The law lays all the burden on the final consumer, namely the households and companies, through an electricity surcharge. This surcharge has increased significantly since the year 2000, making the German electricity prices the highest in Europe. Thanks to its massive support, the number of renewable energy sources has risen to a rate, for which the transmission system operators were not prepared. It is obvious that in order to successfully continue with the Energiewende, the power grid has to be expanded. While the consensus of the population with these subparts is crucial, it is useful to know its levels. This thesis comes to the conclusion that...
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Development Funding of Czech Social Services before and after 1989
Dosedlová, Tereza ; Krpálek, Pavel (advisor) ; Holečková, Markéta (referee)
This thesis deals with basic conditions and creation trends in pursuit of increasing effectivity in funding of social services in the Czech republic. Said trends are distinguished as generally apparent, latent and those followed by decision making government body for administration purposes and in pursuit of sustainability. Time period before 1989 is described mainly as socio-political background for social services funding are based. This thesis is processed as a descriptive and analytical study.
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Development of Meta-Server for Prediction of Mutations Effects on Protein Function
Lisák, Peter ; Burgetová, Ivana (referee) ; Jaša, Petr (advisor)
This bachelor thesis deals with analysis of genomic data, more specifically prediction of effects of mutations on protein function using a protein sequence or tertiary structure. The theoretical introduction describes the basics of genetics and bioinformatics and is followed by description of selected prediction tools such as SIFT, MAPP and AUTO-MUTE. A unified interface for work with different tools is proposed in the thesis. The meta-server interface allows running a computation and collecting results from one site. meta-server combines results of implemented tools and provides a consensual prediction, which is expected to be more accurate than the results from individual tools. Finally, testing of meta-server on the real data and comparisons of predictions with the experimentally obtained results are presented.
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